The Arizona Diamondbacks figured the best approach against a pitcher in his major league debut was to come out aggressive, a plan that worked right away. Eduardo Escobar's three-run home gave Arizona a four-run lead before Los Angeles recorded an out, and the Diamondbacks cruised to an 8-2 victory over the National League West-leading Dodgers on Wednesday. The Dodgers, with the best record in the majors at 55-27, lost for just the second time — both to Arizona in the three-game series — in nine games, while Arizona finished a nine-game homestand 3-6.